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KMID : 0369820110410030147
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Jorunal of Korean Pharmaceutical Sciences
2011 Volume.41 No. 3 p.147 ~ p.151
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Fabrication of Biodegradable Disc-shaped Microparticles with Micropattern using a Hot Embossing Process with Porous Microparticles
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Hwang Ji-Yea
Choy Young-Bin
Seo Soon-Min
Park Jung-Hwan
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Abstract
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This paper demonstrates the development of a method for preparing micropatterned microdiscs in order to increase contact area with cells and to change the release pattern of drugs. The microdiscs were manufactured with hot embossing, where a polyurethane master structure was pressed onto both solid and porous microparticles made of polylacticco-glycolic acid at various temperatures to form a micropattern on the microdiscs. Flat microdiscs were formed by hot embossing of porous microparticles; the porosity allowed space for flattening of the microdiscs. Three types of microgrooves were patterned onto the flat microdiscs using prepared micropatterned molds: (1) 10 μm deep, 5 μm wide, and spaced 2 μm apart; (2) 10 μm deep, 9 μm wide, and spaced 5 μm apart; and (3) 10 μm deep, 50 μm wide, and spaced 50 μm apart. This novel microdisc preparation method using hot embossing to create micropatterns on flattened porous microparticles provides the opportunity for low-cost, rapid manufacture of microdiscs that can be used to control cell adhesion and drug delivery rates.
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KEYWORD
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Biodegradable polymer, Porous microparticle, Embossing, Micropatterning, Microdisc
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